Memory of a Killer is one of the most talked-about new TV dramas of early 2026 — a high-stakes crime thriller starring Patrick Dempsey that blends action, mystery, and the emotional toll of early-onset dementia.
A Fresh, Risky Premise
In Memory of a Killer, Dempsey steps far beyond his Grey’s Anatomy persona to portray Angelo Doyle (aka Angelo Flannery), a seasoned hitman living a carefully hidden double life. By day, Angelo appears to be a mild-mannered photocopier salesman and devoted father in upstate New York; by night, he is a highly skilled, feared contract killer operating in New York City.
The twist? Angelo is beginning to show symptoms of early-onset Alzheimer’s disease, a devastating diagnosis that threatens to unravel his two worlds and put his pregnant daughter Maria (played by Odeya Rush) and others close to him in grave danger.
This blend of crime drama and character study gives the series an intriguing emotional core — Angelo must outwit both his enemies and his failing memory.
Cast, Creators & Production
Memory of a Killer is based on the acclaimed Belgian film De Zaak Alzheimer, itself adapted from a novel, but reimagined as a serialized FOX drama.
Key cast members include:
- Patrick Dempsey as Angelo
- Michael Imperioli as Dutch, Angelo’s longtime friend and crime boss
- Richard Harmon, Peter Gadiot, and Daniel David Stewart in supporting roles
- Gina Torres as FBI Agent Linda Grant, closing in on Angelo’s secret life
The series premiered on January 25, 2026, with a special two-night launch event on FOX, strategically positioned after the NFC Championship game to draw a wide audience
Early Reception & Critics’ Take
Critics have offered mixed reactions to Memory of a Killer. Some praise its fast-paced storytelling and Dempsey’s gritty performance, noting that the premise sets it apart from standard crime procedurals.
However, a number of reviewers describe the execution as uneven — struggling to balance complex plot threads with the emotional depth required for its central theme of dementia. Some reviews soberly note that while the show is engaging and watchable, it doesn’t always fully realize its potential.
Why It Matters
Beyond its thriller façade, Memory of a Killer delves into the psychological impact of memory loss, offering a rare lens on how cognitive decline can affect an individual’s identity, relationships, and moral compass. Whether it becomes a breakout hit or a cult favorite in the crime genre, the series is stirring conversation this season.
With its blend of family drama, moral ambiguity, and taut action, Memory of a Killer is a compelling watch for fans of character-driven thrillers.
